Itraconazole-induced Torsade de Pointes in a patient receiving methadone substitution therapy

Issues. Methadone, a pharmacological agent used to treat heroin dependence is relatively safe, but may cause cardiac arrhythmias in the concurrent presence of other risk factors. Approach and Key Findings. This case report highlights the risk of Torsade de Pointes, a life-threatening cardiac arrhythmia, in a heroin-dependent patient receiving methadone substitution therapy who was prescribed itraconazole for vaginal thrush. The patient presented to the accident and emergency department for chest discomfort and an episode of syncope following two doses of itraconazole (200 mg). Electrocardiogram monitoring at the accident and emergency department showed prolonged rate-corrected QT interval leading to Torsade de Pointes. The patient was admitted for cardiac monitoring, and electrocardiogram returned to normal upon discontinuation of methadone. Implication. This cardiac arrhythmia was most likely as a result of a drug interaction between methadone and itraconazole because the patient presented with no other risk factors. Conclusion. Given the benefits of methadone as a substitution treatment for heroin-dependent individuals, the association between methadone and cardiac arrhythmias is of great concern. Physicians treating heroin-dependent patients on methadone substitution therapy should therefore be cautious of the potential risk of drug interactions that may lead to fatal cardiac arrhythmias

Analyzing Timed Systems Using Tree Automata

Timed systems, such as timed automata, are usually analyzed using their operational semantics on timed words. The classical region abstraction for timed automata reduces them to (untimed) finite state automata with the same time-abstract properties, such as state reachability. We propose a new technique to analyze such timed systems using finite tree automata instead of finite word automata. The main idea is to consider timed behaviors as graphs with matching edges capturing timing constraints. When a family of graphs has bounded tree-width, they can be interpreted in trees and MSO-definable properties of such graphs can be checked using tree automata. The technique is quite general and applies to many timed systems. In this paper, as an example, we develop the technique on timed pushdown systems, which have recently received considerable attention. Further, we also demonstrate how we can use it on timed automata and timed multi-stack pushdown systems (with boundedness restrictions)

Asymptotics of Harish-Chandra expansions, bounded hypergeometric functions associated with root systems, and applications

A series expansion for Heckman-Opdam hypergeometric functions $\varphi_\lambda$ is obtained for all $\lambda \in \mathfrak a^*_{\mathbb C}.$ As a consequence, estimates for $\varphi_\lambda$ away from the walls of a Weyl chamber are established. We also characterize the bounded hypergeometric functions and thus prove an analogue of the celebrated theorem of Helgason and Johnson on the bounded spherical functions on a Riemannian symmetric space of the noncompact type. The $L^p$-theory for the hypergeometric Fourier transform is developed for $0<p<2$. In particular, an inversion formula is proved when $1\leq p <2$

Two dimensional fermions in three dimensional YM

Dirac fermions in the fundamental representation of SU(N) live on the surface of a cylinder embedded in $R^3$ and interact with a three dimensional SU(N) Yang Mills vector potential preserving a global chiral symmetry at finite $N$. As the circumference of the cylinder is varied from small to large, the chiral symmetry gets spontaneously broken in the infinite $N$ limit at a typical bulk scale. Replacing three dimensional YM by four dimensional YM introduces non-trivial renormalization effects.Comment: 21 pages, 7 figures, 5 table

Disordered social media use and risky drinking in young adults:Differential associations with addiction-linked traits

Background Excessive or compulsive use of social media has been likened to an addiction, similar to other behavioural addictions such as pathological gambling or Internet addiction. This investigation sought to determine the degree to which personality traits associated with such disordered social media use overlap with those known to predict problematic substance use, with use of the most commonly abused legal substance alcohol as an example of the latter. Method Well‐known indices of disordered social media use, risky or problematic alcohol use, and the personality traits alexithymia, reward sensitivity, narcissism, and impulsivity were administered online to 143 men and women aged 18–35-years who were regular users of social media. The traits examined had previously been linked to substance misuse for a variety of substances, including alcohol, as presumed predisposing factors. Results After controlling for age, gender, and social desirability in hierarchical regressions, disordered social media use was predicted by narcissism, reward sensitivity, and impulsivity, whereas risky alcohol use was predicted by narcissism, alexithymia, and impulsivity. The ability of narcissism to predict disordered social media use was mediated by reward sensitivity, which was not the case for risky drinking. Conclusions Present results point to similarities and differences in addiction‐linked traits when comparing disordered social media use to risky or problematic substance use

struc2vec: Learning Node Representations from Structural Identity

Structural identity is a concept of symmetry in which network nodes are identified according to the network structure and their relationship to other nodes. Structural identity has been studied in theory and practice over the past decades, but only recently has it been addressed with representational learning techniques. This work presents struc2vec, a novel and flexible framework for learning latent representations for the structural identity of nodes. struc2vec uses a hierarchy to measure node similarity at different scales, and constructs a multilayer graph to encode structural similarities and generate structural context for nodes. Numerical experiments indicate that state-of-the-art techniques for learning node representations fail in capturing stronger notions of structural identity, while struc2vec exhibits much superior performance in this task, as it overcomes limitations of prior approaches. As a consequence, numerical experiments indicate that struc2vec improves performance on classification tasks that depend more on structural identity.Comment: 10 pages, KDD2017, Research Trac

Polymerase chain reaction in clinical practice

One of the most heralded developments in basic science to reach clinical application in recent years has been the Polymerase Chain Reaction (PCR). PCR has been applied in various areas of clinical medicine including rapid diagnosis of viral, bacterial, fungal and parasitic disease, the diagnosis and prediction of inherited disease, the detection of an association between certain viruses and specific cancers, the detection of organ transplant rejection and HLA subtyping. In basic research PCR is useful in identification of point mutation, deletion, insertions, rearrangements, amplifications and translocations

Numerical computation of the beta function of large N SU(N) gauge theory coupled to an adjoint Dirac fermion

We use a single site lattice in four dimensions to study the scaling of large N Yang-Mills field coupled to a single massless Dirac fermion in the adjoint representation. We use the location of the strong to weak coupling transition defined through the eigenvalues of the folded Wilson loop operator to set a scale. We do not observe perturbative scaling in the region studied in this paper. Instead, we observe that the scale changes very slowly with the bare coupling. The lowest eigenvalue of the overlap Dirac operator is another scale that shows similar behavior as a function of the lattice coupling. We speculate that this behavior is due to the beta function appoaching close to a zero.Comment: 16 pages, 9 figures, revised version DOES NOT match the published version in Physical Review